Evidence map›Paper›PMID 40627118›Full record

ArticleCardiovascular engineering and technology2025

Demonstration of a Mechanical External Biventricular Assist Device for Resuscitative Thoracotomy.

Kristof Sarosi, Thomas Kummer, Thomas Roesgen, Stijn Vandenberghe, Stefanos Demertzis, Patrick Jenny

Abstract read
In one paragraph

Article in Cardiovascular engineering and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Direct Cardiac Compression Device for Short-Term Mechanical Circulatory Support.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristof SarosiDepartment of Mechanical and Process Engineering, Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland. ksarosi@ethz.ch.ORCID 0009-0006-1197-5956
Thomas KummerDepartment of Mechanical and Process Engineering, Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.
Thomas RoesgenDepartment of Mechanical and Process Engineering, Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.
Stijn VandenbergheCardiovascular Engineering, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Stefanos DemertzisFaculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
Patrick JennyDepartment of Mechanical and Process Engineering, Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeResuscitative thoracotomy, a high-risk procedure involving open heart massage, serves as a last resort for life-threatening conditions like penetrating chest wounds, severe blunt trauma, or surgery-related cardiac arrest. However, its success rate remains low, even when primarily carried out by highly trained specialists. This research investigates the potential of an external biventricular assist device (BiVAD). By replacing open heart massage with our BiVAD device during resuscitative thoracotomy, we aim to achieve sufficient cardiac output, maintain physiological pressure levels, and potentially improve patient survival in these critical situations.

methodsThe proposed BiVAD system features a 3D printed patch design for direct cardiac attachment, an actuation device, and a vacuum pump. The straightforward design allows quick application in emergency situations. The BiVAD system was tested in an in vitro hydraulic mock circulation, utilizing a silicone heart. Three actuation modes were tested for proof-of-concept: manual patch actuation, standard cardiac hand massage, and utilizing full capabilities of our BiVAD patch system with actuation device operation. Overall performance was assessed on ventricular pressure and flow rate data.

resultsFocusing on achieving the optimal cardiac output of 1.5 L/min (critical for patient survival), we tested our patch system against cardiac hand massage at a fixed rate of 60 bpm. The results include raw and statistically evaluated flow rate and pressure measurements for both the left and the right ventricle. Notably, our BiVAD system not only achieved to operate in the range of required cardiac output but also significantly reduced peak pressure in both ventricles compared to standard cardiac hand massage.

conclusionThis initial evaluation using a silicone heart model demonstrates the potential of our BiVAD system to achieve sufficient cardiac output while reducing peak pressure compared to cardiac hand massage. Further development holds promise for effective cardiac support in resuscitative thoracotomy.

Indexed as

Heart-Assist DevicesResuscitationThoracotomyVentricular Function, LeftVentricular Function, RightCardiac OutputHeart MassageHemodynamicsHumansModels, CardiovascularPrinting, Three-DimensionalProsthesis DesignVentricular PressureAssisted circulationCardiac outputCardiopulmonary resuscitationEmergency heart surgeryResuscitative thoracotomyVentricular assist device

Identifiers

PMID40627118
PMCPMC12528232

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.