ArticleJournal of endocrinological investigation2025
Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathy.
Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Trial
- Multi-layer gut microbiome variation in type 2 diabetes despite preserved higher-order community structure.Frontiers in microbiology · 2026Article
- Mapping the gut microbiota-diabetic peripheral neuropathy research landscape: a bibliometric analysis of emerging trends and translational frontiers.Frontiers in endocrinology · 2026Article
- Intratumoral Collinsella aerofaciens exhibits antitumor activity in endometrial carcinoma through activation of the p53 signaling pathway.Journal of translational medicine · 2025Article
- Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis.Frontiers in endocrinology · 2025Article
- Integrating gut microbiota into multidisciplinary perspectives on diabetic neuropathy.Frontiers in endocrinology · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
purposeDiabetic peripheral neuropathy (DPN) is one of the most common complications of type 2 diabetes mellitus (T2DM). In recent years, it has been reported that the progression of DPN is associated with altered gut microbiota and serum metabolites. However, the alterations of the gut microbiota and interaction with metabolites are not well understood in DPN patients. Therefore, we compared the gut microbiota and fecal and serum metabolic profiles of DPN and comprehensively analyzed the potential mechanisms of DPN.
methodsA total of 50 patients were divided into two groups: T2DM group without DPN (T2DM group) and T2DM group with DPN (DPN group). Fecal and serum samples of all patients were collected, and serum metabolites were determined by
resultsBacteria at the genus level in 8 and the species level in 13, and 28 fecal metabolites, and 5 serum metabolites were significantly altered in DPN patients. In particular, genus Faecalibacterium, species Collinsella_aerofaciens, fecal glycocholic acid and serum formate were significantly reduced in DPN, while genus Megamonas, fecal maleamic acid and serum uric acid (UA) were enriched. These changes are related to bile acid metabolism, amino acid metabolism, and mitochondrial dysfunction, as well as significantly correlated with VAS score, TCSS score and electromyography indicators.
conclusionThis study discovered the abnormal gut microbiota in DPN patients, with alterations in fecal and serum metabolism. It is speculated that the gut microbiota may lead to metabolic imbalance, accelerating the DPN progression. Multi-omics analysis was used to identify the possible mechanism of the gut microbiota-metabolism-mitochondrial axis in the progression of DPN, which may provide a potential therapeutic target for the diagnosis and treatment of DPN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.