Evidence map›Paper›PMID 40627034›Full record

ArticleMikrochimica acta2025

Synergistic azo reaction and electroextraction in SPME-SERS for direct determination of aromatic amines in biofluids with minimal matrix interference.

Yadi Liu, Shu Li, Xinyuan Guo, Tong Wang, Dawei Yang, Jinhua Zhan, Jing Chen

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yadi LiuSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Shu LiSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Xinyuan GuoSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Tong WangSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Dawei YangZhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital, Liaocheng, 252000, China.
Jinhua ZhanSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Jing ChenSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China. jingchen@sdu.edu.cn.ORCID 0000-0001-5216-3061

Funding

Foundation for Innovative Research Groups of the National Natural Science Foundation of China Grant No. 22276110Key Technology Research and Development Program of Shandong Province 2021CXGC011202Natural Science Foundation of Shandong Province ZR2024MA091
6 · The paper itself

Abstract

A solid-phase microextraction-SERS (SPME-SERS) analysis system was enhanced by the synergistic integration of azo reaction and electroextraction (Azo/EEx/SPME-SERS) to directly determine aromatic amines in serum and urine. Azo reactions selectively converted aromatic amines (e.g., aniline) into positively charged derivatives, which were selectively absorbed onto a rough silver SERS substrate via charge-selective electroextraction (- 0.2 V), excluding anionic interferents. Electroextraction-accelerated mass transfer and real-time SERS detection enabled rapid preconcentration and spectral acquisition under 3 min. The azo reaction increased the Raman scattering cross-section of aniline, and electroextraction reduced the distance of azo aniline to the SERS hot spots. This enabled low detection limits (aniline, 0.005 µg·mL

Indexed as

AminesAniline CompoundsAzo CompoundsSolid Phase MicroextractionSpectrum Analysis, RamanHumansLimit of DetectionSilverAminesanilineAniline CompoundsAzo CompoundsSilverAromatic aminesAzo reactionElectroextractionSolid phase micro extractionSurface-enhanced Raman spectroscopy

Identifiers

PMID40627034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.