Trial reportEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2025
A comparison of antiplatelet and oral anticoagulation strategies to prevent cerebral microembolism after transcatheter aortic valve implantation: the AUREA trial.
Trial report in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Antithrombotic strategies after TAVI in light of cerebral microembolism.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effectiveness of oral anticoagulation (OAC) or dual antiplatelet therapy (DAPT) in reducing subclinical brain infarcts after transcatheter aortic valve implantation (TAVI) remains unclear.
aimsWe aimed to compare the efficacy of DAPT versus OAC in preventing cerebral microembolism during the first 3 months post-TAVI, assessed by diffusion-weighted magnetic resonance imaging (DW-MRI).
methodsPatients with aortic stenosis and no indication for OAC were randomly assigned to receive either OAC (acenocoumarol) or DAPT (aspirin+clopidogrel) for 3 months post-TAVI. Brain DW-MRI was performed at baseline (0-3 days pre-TAVI) and at 6 and 90 days post-TAVI. The primary objective was the proportion of patients with new cerebral emboli on DW-MRI at 6 and 90 days.
resultsOf the 123 patients included in the study, 3.3% had new cerebral emboli on the baseline MRI prior to TAVI. At 6 days post-TAVI, new cerebral emboli were observed in 81.4% of OAC patients versus 69.8% of DAPT patients (p=0.209), and at 90 days, in 8.0% versus 8.2%, respectively (p=0.879). However, DAPT patients had a lower mean total emboli volume at 6 days (265.9 mm³ vs 303.4 mm³; p=0.019) and cumulatively at 6+90 days (266.45 mm³ vs 331.10 mm³; p=0.008).
conclusionsIn patients without an indication for OAC, an OAC strategy for 3 months post-TAVI did not show any benefit over an antiplatelet strategy in preventing cerebral microembolism. Patients treated with DAPT showed a lower mean volume of brain damage on DW-MRI during the 90 days following TAVI compared to those treated with acenocoumarol.
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