Evidence map›Paper›PMID 40626943›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Macromolecule-Driven Supramolecular Polymerization Induced by Crowding Effects.

Joost J B V D Tol, Magda M J Dekker, Ádám Müller, Puck Springintveld, E W Meijer, Ghislaine Vantomme

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Macromolecule-Driven Supramolecular Polymerization Induced by Crowding Effects.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joost J B V D Tol *Macromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
Magda M J Dekker *Macromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
Ádám MüllerMacromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
Puck SpringintveldMacromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
E W MeijerMacromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
Ghislaine VantommeMacromolecular and Organic Chemistry Group, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.ORCID https://orcid.org/0000-0003-2036-8892

Funding

Dutch Ministry of Education, Culture and Science 024.001.035European Research Council 788618National Growth Fund project 1420578
6 · The paper itself

Abstract

Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored. Here, we systematically investigate how excluded volume effects influence supramolecular polymerizations in organic media. We employ various discotic supramolecular monomers that assemble sequentially into polymers and kinetically-controlled higher-order aggregates (HOAs) only in the presence of macromolecular crowders. The phase diagram of the supramolecular assemblies reveals a strong dependence on the macromolecule concentration, size, and polarity, which can be tuned to control polymerization. Remarkably, at high crowder concentrations, large condensed and aligned assemblies were observed in dried samples, suggesting a transition to phase-separated states. By testing different monomers, macromolecules, and solvents, we establish the general applicability and versatility of macromolecular crowding in guiding supramolecular polymerization. This work provides fundamental insights into assembly processes in crowded environments and opens new avenues for applying macromolecular crowding beyond aqueous systems.

Indexed as

CrowdingMacromoleculesSequestrationSupramolecular polymerization

Identifiers

PMID40626943
PMCPMC12402893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.