Evidence map›Paper›PMID 40626890›Full record

ArticleImmunity, inflammation and disease2025

Fatty Acids and Inflammatory Protein Biomarkers From Coronavirus Disease 2019 Patients.

Niharika Bala, Alaa H Habib, Marianne Kozuch, Nancy D Denslow, Neha S Dhaliwal, Anna H Owings, Sarah C Glover, Abdel A Alli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Niharika BalaDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, Florida, USA.
Alaa H HabibDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, Florida, USA.
Marianne KozuchDepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, USA.
Nancy D DenslowDepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, USA.
Neha S DhaliwalDepartment of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Anna H OwingsDepartment of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Sarah C GloverDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Abdel A AlliDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0003-4381-1172

Funding

Initiation of immune responses to SARS COV2 in the oral cavity and upper airwayR01DE031928 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GILL DIAMOND, SARAH C GLOVER · 2022 to 2026
$3.8M
NIDCR NIH HHS R01 DE031928This study was funded by an NIH R01 Grant R01DE031928-01A1 (to S.C.G.) and foundation funds from the University of Mississippi Medical Center.
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated with systemic inflammation. Inflammation is an important process that follows infection and facilitates the body's innate immune response and repair of damaged tissue. Polyunsaturated fatty acids play an important role in the inflammatory process. These lipids can target transcription factors to modulate gene expression and protein function.

methodsHere, we performed a fatty acid methyl ester (FAME) analysis and immunoassays to evaluate whether differences in basal levels of different types of biomarkers can be detected in freshly frozen plasma samples from patients with and without COVID-19.

resultsFAME analysis showed a decrease in arachidic acid and myristic acid, but an increase in caprylic acid, palmitic acid, and eicosenoic acid in the plasma of COVID-19 patients compared to non-COVID-19 patients. Multiple chemokines including IP-10, MCP-1, and MIP-1 beta were increased in the COVID-19 group compared to the non-COVID-19 group. Similarly, cytokines including IL-1 alpha and IL-8, and cell adhesion and inflammatory response markers including ICAM-1 and E-selectin were greater in the plasma of COVID-19 patients compared to non-COVID-19 patients.

conclusionsA baseline signature of specific polyunsaturated fatty acids, cytokines, and chemokines present in the plasma after COVID-19 viral infection may serve as biomarkers that can be useful in various applications including determination of severity of infection, indication of disease prognosis, and consideration for therapeutic options.

Indexed as

COVID-19Fatty AcidsSARS-CoV-2AdultAgedBiomarkersCytokinesFemaleHumansInflammationMaleMiddle AgedBiomarkersCytokinesFatty AcidschemokinesCOVID‐19cytokinesfatty acidsinflammationSARS‐CoV‐2

Identifiers

PMID40626890
PMCPMC12235974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.