Evidence map›Paper›PMID 40626889›Full record

ArticleAntimicrobial agents and chemotherapy2025

Mutations in the proximal binding site and F-loop of AdeJ confer resistance to efflux pump inhibitors.

Aysegul Saral Sariyer, Inga V Leus, Rushikesh Tambat, Mithila Farjana, Marcela Olvera, Shalini J Rukmani, Emrah Sariyer, Jeremy C Smith, Jerry M Parks, John K Walker and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aysegul Saral SariyerDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Inga V LeusDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID 0000-0001-8906-717X
Rushikesh TambatDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Mithila FarjanaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Marcela OlveraDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Shalini J RukmaniBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Emrah SariyerDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Jeremy C SmithBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Jerry M ParksBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.ORCID 0000-0002-3103-9333
John K WalkerDepartment of Pharmacology and Physiology, School of Medicine, Saint Louis University, St. Louis, Missouri, USA.
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID 0000-0001-8929-4727

Funding

Transport across two membranes by AcrAB-TolC complexR01AI052293 · NIAID · UNIVERSITY OF OKLAHOMA NORMAN · PI ZGURSKAYA, HELEN I · 2003 to 2024
$7.7M
Permeability Barriers of Gram-negative Pathogens and Approaches to Bypass ThemR01AI132836 · NIAID · UNIVERSITY OF OKLAHOMA · PI HELEN I ZGURSKAYA · 2017 to 2026
$4.3M
Transport Across Two Membranes by AcrAB-TolC ComplexR56AI052293 · NIAID · UNIVERSITY OF OKLAHOMA · PI ZGURSKAYA, HELEN I · 2008 to 2008
$360k
Advanced Research Projects AgencyNational Institute of Allergy and Infectious Diseases R01AI132836NIAID NIH HHS R01 AI052293NIAID NIH HHS R01 AI132836NIAID NIH HHS R56 AI052293
6 · The paper itself

Abstract

Multidrug efflux is one of the major mechanisms of antibiotic resistance in gram-negative bacteria. Inhibitors of efflux pumps potentiate the activities of antibiotics, and their discovery could lead to new therapeutic options. The AdeIJK pump in

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsMembrane Transport ProteinsBinding SitesDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsMutationAnti-Bacterial AgentsBacterial ProteinsMembrane Transport ProteinsAcinetobacterantibiotic resistanceefflux pump inhibitorsmultidrug efflux

Identifiers

PMID40626889
PMCPMC12326959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.