ReviewChemical Society reviews2025
Dynamic combinatorial chemistry directed by proteins and nucleic acids: a powerful tool for drug discovery.
Review in Chemical Society reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multifunctional Tailoring of Fertilizer Composites Directly Derived From Phosphate Rock.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-directed dynamic combinatorial chemistry (P-D DCC) is a powerful strategy for identifying ligands to protein targets of pharmacological significance. It leverages a thermodynamic templated effect, where proteins selectively amplify high-affinity binders. In contrast, although nucleic acids play critical roles in gene regulation and disease and offer significant therapeutic potential, they remain underexplored in drug discovery. While P-D DCC has been widely applied, the use of nucleic acid-directed dynamic combinatorial chemistry (NA-D DCC) is relatively limited. Expanding these methodologies is essential for tackling emerging infectious diseases and advancing therapeutic development. This review examines the applications, experimental design considerations, recent advancements, and P-D DCC and NA-D DCC perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.