ArticleJournal of the American Chemical Society2025
DNA Aptamer-Guided Glycomimetics for Developmental Stage-Specific Glycocalyx Engineering to Control Stem Cell Differentiation.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Heparan sulfate glycosaminoglycans in the stem cell glycocalyx are crucial in controlling growth factor activity during development. Augmenting the surface of stem cells with synthetic heparan sulfate mimetics with defined compositions and growth factor binding profiles has emerged as a promising strategy to fine-tune cellular signaling responses and differentiation. However, current glycocalyx engineering methods lack specificity for stem cells or require prior genetic manipulation, limiting their applicability in a therapeutic context. Here, we report a heparan sulfate mimetic containing a DNA aptamer with affinity for the membrane-associated pluripotency marker, alkaline phosphatase, that can be selectively targeted to the surface of embryonic stem cells. The glycomimetic-enhanced fibroblast growth factor 2 recruitment to the stem cell surface activated signaling through the mitogen-activated protein kinase pathway and promoted neural differentiation. While the present work targets pluripotent cells specifically, it can be more broadly applicable to progenitor cells at other developmental stages to better control their differentiation and enhance their therapeutic potential.
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Registered trials
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