ArticleMicrobiology spectrum2025
Epstein-Barr virus type 2 infection is associated with higher viral loads in pediatric tonsils from western Kenya.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epstein-Barr virus (EBV) is an etiologic agent of endemic Burkitt lymphoma (BL), a prevalent pediatric cancer in sub-Saharan Africa. There are two known types of EBV, EBV Type-1 (EBV-1) and EBV Type-2 (EBV-2), both found in eBL patients. To determine the EBV load and type dynamics within the tonsils, saliva, whole blood, and plasma, we enrolled 102 children aged 1-14 undergoing tonsillectomy in a malaria holoendemic region of western Kenya. Additionally, we investigated EBV-2 cell type preference in tonsillar mononuclear cells (TMCs). Saliva, whole blood, and tonsillar tissue were collected at the time of enrollment. Whole blood was centrifuged to separate plasma from red blood cells, and tonsillar mononuclear cells (TMCs) were isolated from tonsils using a ficoll gradient. Using qPCR, we assessed EBV load and type in TMCs, plasma, whole blood, and saliva. Additionally, a subset of samples was subject to cell sorting to determine the infected cell population. We found that EBV loads were significantly higher in TMCs compared to whole blood (
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