ArticleeLife2025
Homophilic wiring principles underpin neuronal network topology in vitro.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Estimating Brain Similarity Networks With Diffusion MRI.Human brain mapping · 2025Article
- Article
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- Metric structural human connectomes: Localization and multifractality of eigenmodes.Network neuroscience (Cambridge, Mass.) · 2025Article
- Brain wiring economics, network organisation and population-level genomics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Early adversity changes the economic conditions of mouse structural brain network organization.Developmental psychobiology · 2023Article
- Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays.Frontiers in neuroscience · 2022Article
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Authors and funding
15 authors.
Funding
Abstract
Economic efficiency has been a popular explanation for how networks self-organize within the developing nervous system. However, the precise nature of the economic negotiations governing this putative organizational principle remains unclear. Here, we address this question further by combining large-scale electrophysiological recordings to characterize the functional connectivity of developing neuronal networks in vitro, with a generative modeling approach capable of simulating network formation. We find that the best fitting model uses a homophilic generative wiring principle in which neurons form connections to other neurons which are spatially proximal and have similar connectivity patterns to themselves. Homophilic generative models outperform more canonical models in which neurons wire depending upon their spatial proximity either alone or in combination with the extent of their local connectivity. This homophily-based mechanism for neuronal network emergence accounts for a wide range of observations that are described, but not sufficiently explained, by traditional analyses of network topology. Using rodent and human neuronal cultures, we show that homophilic generative mechanisms can accurately recapitulate the topology of emerging cellular functional connectivity, representing an important wiring principle and determining factor of neuronal network formation in vitro.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.