Evidence map›Paper›PMID 40626693›Full record

ReviewDiagnostic and interventional radiology (Ankara, Turkey)2026

Foundation models for radiology: fundamentals, applications, opportunities, challenges, risks, and prospects.

Tugba Akinci D'Antonoli, Christian Bluethgen, Renato Cuocolo, Michail E Klontzas, Andrea Ponsiglione, Burak Kocak

Abstract readReview
In one paragraph

Review in Diagnostic and interventional radiology (Ankara, Turkey), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tugba Akinci D'AntonoliUniversity Hospital Basel, Department of Diagnostic and Interventional Neuroradiology, Basel, Switzerland.ORCID 0000-0002-7237-711X
Christian BluethgenUniversity Hospital Zurich, Institute for Diagnostic and Interventional Radiology, Zurich, Switzerland.ORCID 0000-0001-7321-5676
Renato CuocoloDepartment of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy.ORCID 0000-0002-1452-1574
Michail E KlontzasUniversity of Crete School of Medicine, Artificial Intelligence and Translational Imaging (ATI) Lab, Department of Radiology, Crete, Greece.ORCID 0000-0003-2731-933X
Andrea PonsiglioneUniversity of Naples Federico II, Department of Advanced Biomedical Sciences, Naples, Italy.ORCID 0000-0002-0105-935X
Burak KocakBaşakşehir Çam and Sakura City Hospital, Department of Radiology, İstanbul, Türkiye.ORCID 0000-0002-7307-396X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foundation models (FMs) represent a significant evolution in artificial intelligence (AI), impacting diverse fields. Within radiology, this evolution offers greater adaptability, multimodal integration, and improved generalizability compared with traditional narrow AI. Utilizing large-scale pre-training and efficient fine-tuning, FMs can support diverse applications, including image interpretation, report generation, integrative diagnostics combining imaging with clinical/laboratory data, and synthetic data creation, holding significant promise for advancements in precision medicine. However, clinical translation of FMs faces several substantial challenges. Key concerns include the inherent opacity of model decision-making processes, environmental and social sustainability issues, risks to data privacy, complex ethical considerations, such as bias and fairness, and navigating the uncertainty of regulatory frameworks. Moreover, rigorous validation is essential to address inherent stochasticity and the risk of hallucination. This international collaborative effort provides a comprehensive overview of the fundamentals, applications, opportunities, challenges, and prospects of FMs, aiming to guide their responsible and effective adoption in radiology and healthcare.

Indexed as

Artificial IntelligenceRadiologyHumansArtificial intelligenceChatGPTdeep learningfoundation modelslarge language modelsmedical imagingradiology

Identifiers

PMID40626693
PMCPMC13136656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.