Evidence map›Paper›PMID 40626672›Full record

ArticlePathologica2025

Primary leiomyosarcoma of bone: a clinicopathologic and immunohistochemical study of 142 cases.

Elena Bellan, Alberto Righi, Marco Gambarotti, Stefania Benini, Dino Gibertoni, Marilena Cesari, Giuseppe Bianchi, Piero Picci, Angelo P Dei Tos, Marta Sbaraglia

Abstract read
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Primary malignant bone tumours-part II].Radiologie (Heidelberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena BellanDepartment of Integrated Diagnostics, Azienda Ospedale-Università Padova.
Alberto RighiDepartment of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Marco GambarottiDepartment of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Stefania BeniniDepartment of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Dino GibertoniEpidemiology and Statistics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Marilena CesariOsteoncology, Soft Tissue and Bone Sarcomas, Innovative Therapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Giuseppe BianchiUnit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Piero PicciDepartment of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Angelo P Dei TosDepartment of Integrated Diagnostics, Azienda Ospedale-Università Padova.
Marta SbaragliaDepartment of Integrated Diagnostics, Azienda Ospedale-Università Padova.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leiomyosarcoma is a rare malignant mesenchymal tumor characterized by smooth muscle differentiation. It typically arises in both visceral and somatic soft tissues, while involvement of bone being exceptionally uncommon. Although primary leiomyosarcoma of bone has been a subject of ongoing debate, the advent of immunohistochemistry has reduced the misclassification of other sarcomas, such as fibrosarcoma and undifferentiated pleomorphic sarcoma, facilitating the accurate identification of true primary LMSB cases. To date, just over 200 well-documented LMSB cases have been published in English-language literature. Despite this, understanding of its clinical behaviour and factors influencing patient outcomes remains limited. In this study, we present the clinical, pathological, and immunohistochemical findings from 142 cases of primary bone leiomyosarcoma including extended follow-up data.

Indexed as

Biomarkers, TumorBone NeoplasmsLeiomyosarcomaAdultAgedAged, 80 and overFemaleHumansImmunohistochemistryMaleMiddle AgedYoung AdultBiomarkers, Tumorleiomyosarcomamalignant mesenchymal tumorPrimary bone sarcomasrare bone tumor

Identifiers

PMID40626672
PMCPMC12236143

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.