Evidence map›Paper›PMID 40626666›Full record

ArticlePathologica2025

Consensus document on preoperative diagnostic procedures in breast lesions.

Stefano Marletta, Isabella Castellano, Francesca Caumo, Carmen Criscitiello, Patrizia Frittelli, Donatella Santini, Daniela Terribile, Daniela Bernardi, Marina Bortul, Massimo Calabrese and 14 more

Abstract readConsensus Statement
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Stefano MarlettaDivision of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy.
Isabella CastellanoDepartment of Medical Sciences, University of Turin, Italy.
Francesca CaumoVeneto Institute of Oncology (IOV) IRCCS, Padua, Italy.
Carmen CriscitielloDivision of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy.
Patrizia FrittelliUOC Chirurgia senologica, Ospedale Isola Tiberina Gemelli Isola, Rome, Italy.
Donatella SantiniDepartment of Pathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
Daniela TerribileDivision of Breast Surgery, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Daniela BernardiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele (Milan), Italy.
Marina BortulSSD Breast Unit, ASUGI Units, Trieste, Italy.
Massimo CalabreseIRCCS Hospital Policlinico San Martino, Genoa, Italy.
Giuseppe CatanutoHumanitas University Istituto Clinico Catanese, Catania, Italy.
Maria Grazia CattaniUnit of Anatomic Pathology, AUSL Bologna, Ospedale Bellaria, Bologna, Italy.
Leopoldo CostarelliDepartment of Pathology, San Giovanni-Addolorata Hospital, Rome, Italy.
Giulia D'AmatiDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Italy.
Nicola FuscoDivision of Pathology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Oreste GentiliniUniversità Vita-Salute San Raffaele, Milano, Italy; IRCCS Ospedale San Raffaele, Milano, Italy.
Moira RagazziPathology Unit, Azienda USL-IRCCS di Reggio Emilia, Italy.
Gianni SaguattiUO Senologia, Ospedale Bellaria, AUSL Bologna, Italy.
Alfredo SantinelliUOC Anatomia Patologica, Azienda Sanitaria Territoriale di Pesaro-Urbino, Pesaro, Italy.
Cristian ScatenaDivision of Pathology, Department of Translational Research & New Technologies in Medicine & Surgery, University of Pisa, Pisa, Italy.
Grazia SciancaleporeASO "S. Croce e Carle", Cuneo, Italy.
Francesca PietribiasiDivision of Pathology, Santa Croce Hospital, Moncalieri, Turin, Italy.
Anna SapinoCandiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy.
Antonio RizzoDivision of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, percutaneous sampling via core needle or vacuum-assisted biopsy is the primary choice to guide the management of patients with clinical or screen-detected breast lesions. Preoperative biopsies allow physicians to get pathological diagnoses as well as key prognostic and predictive data about the nature of the investigated process. Namely, adequate biopsy sampling is crucial for assigning lesions to one diagnostic category (B1-B5). Similarly, evaluating morphological (histotype, vascular invasion, necrosis, etc.) and immunohistochemical/molecular features (ER, PR, Ki-67, and HER2) is the key to address the most effective therapies, especially in the neoadjuvant setting. The multidisciplinary team should always discuss the results of percutaneous biopsies, whose global integration with clinical and radiological findings will drive the adoption of specific treatment options, particularly for uncertain (B3) and suspicious/malignant (B4-B5) lesions. In the present work, we report a comprehensive overview of breast percutaneous biopsy techniques, diagnostic categories, and multidisciplinary management based on widely acknowledged evidence of good clinical practice.

Indexed as

BreastBreast NeoplasmsPreoperative CareBiomarkers, TumorBiopsyBiopsy, Large-Core NeedleFemaleHumansBiomarkers, Tumorbreast cancerconsensusmultidisciplinary managementpreoperative biopsy

Identifiers

PMID40626666
PMCPMC12236140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.