ArticlemBio2025
Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus.
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Global evolutionary landscape of H11 avian influenza and initial isolates identified in Xinjiang, China.Emerging microbes & infections · 2026Article
- Epidemiological and Phylogenetic Analysis of Reassorted H10Nx Avian Influenza Viruses in Guangdong Province, China.Influenza and other respiratory viruses · 2026Article
- Contribution of E190D and Q226H Mutations in HA to the Receptor-Binding Profile of D1.1 Genotype H5N1 Viruses.Influenza and other respiratory viruses · 2026Article
- Influenza virus infection during pregnancy: a review of risk factors, pathogenic mechanisms, and prevention strategies.Frontiers in immunology · 2026Review
- Divergent Avian Influenza H10 Viruses from Sympatric Waterbird Species in Italy: Zoonotic Potential Assessment by Molecular Markers.Microorganisms · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Recently, human infections with H10 influenza viruses, including H10N8 and H10N3, have been reported. In January 2024, a case of H10N5 and H3N2 co-infection was reported in Zhejiang Province, China, which is the first human infection with H10N5 avian influenza virus (AIV) globally. Almost simultaneously, we isolated a wild bird-derived H10N5 strain similar to the human H10N5 strain. To assess the public health risk, it is necessary to understand the zoonotic characteristics of these novel H10N5 viruses. Here, we evaluated the biological characteristics of human H10N5, wild bird H10N5, as well as poultry H10N8 IMPORTANCE: In 2024, the H10N5 AIV was first reported to infect humans. Concurrently, we isolated a strain of H10N5 from wild birds that was highly similar to the human H10N5 strain. However, the zoonotic potential and the associated public health risks of the H10N5 virus remain unclear. In this study, we systematically evaluated the replication characteristics of human H10N5, wild bird H10N5, and poultry H10N8 in human lung epithelial cells, the virulence in mice, the transmission capabilities in guinea pigs, and the receptor-binding properties. Our results demonstrate that these novel H10N5 viruses have not yet acquired the ability to transmit in guinea pigs, but they possess the potential to infect mammals. These findings provide timely insights and warnings for the development of public health prevention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.