Evidence map›Paper›PMID 40626649›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2025

Polio virotherapy provokes MDA5 signaling and CD4

Matthias Gromeier, Michael C Brown

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Viral Microglia Reprogramming Clears Oligomeric Neurotoxic Debris.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthias GromeierThe Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-4538-0302
Michael C BrownThe Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-3957-1164

Funding

Innate Antiviral Signals for Cancer ImmunotherapyR01NS108773 · NINDS · DUKE UNIVERSITY · PI Matthias Gromeier, Smita K. Nair · 2018 to 2026
$3.3M
Resolving Spatiotemporal Dynamics of Recombinant Poliovirus ImmunotherapyR01CA281320 · NCI · DUKE UNIVERSITY · PI Matthias Gromeier · 2023 to 2026
$1.7M
Reviving cancer immune surveillance with CD4 T cell helpR00CA263021 · NCI · DUKE UNIVERSITY · PI BROWN, MICHAEL CLAVON · 2022 to 2024
$737k
Reviving cancer immune surveillance with CD4 T cell helpK99CA263021 · NCI · DUKE UNIVERSITY · PI BROWN, MICHAEL CLAVON · 2021 to 2021
$105k
NCI NIH HHS K99 CA263021NCI NIH HHS K99CA263021, R00CA263021NCI NIH HHS R00 CA263021NCI NIH HHS R01 CA281320NCI NIH HHS R01CA281320NINDS NIH HHS R01 NS108773NINDS NIH HHS R01NS108773
6 · The paper itself

Abstract

SUMMARYThere is overwhelming evidence that antitumor CD8

Indexed as

CD4-Positive T-LymphocytesNeoplasmsOncolytic VirotherapyPoliovirusAnimalsCD8-Positive T-LymphocytesHumansImmunity, InnateSignal TransductionVaccinationanticancer therapydendritic cellsimmunotherapyinterferonsmacrophagesMDA5microgliapoliovirusrecallRNA

Identifiers

PMID40626649
PMCPMC12326335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.