ReviewNucleic acids research2025
The biological and evolutionary consequences of competition between DNA sequences that benefit the cell and DNA sequences that benefit themselves.
Review in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- On the origin, evolution, and maintenance of RNA editing.Nucleic acids research · 2025Review
- Assembly and Comparative Analysis of Complete Mitochondrial Genome Sequence of Endangered Medicinal PlantCurrent issues in molecular biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mobile genetic elements (e.g. transposons and introns) are genomic parasites, DNA sequences that can proliferate within host genomes. In prokaryotes, these elements are minimized by purifying selection and host-cell defenses. In eukaryotes, however, these parasitic sequences may comprise most of the genome. This extreme imbalance in eukaryotes is maintained by a metabolically quiescent germline through which the genomic parasites are transmitted to the next generation via gametes and spread throughout the population via sexual reproduction. Some eukaryotes avoid the threat posed by genomic parasites by eliminating them from somatic cells, whereas others retain the parasites in somatic cells and attempt to suppress them by epigenetic silencing mechanisms. Here, we review the evidence for the ongoing competition between host and parasite for genome occupancy. We conclude that defenses against mobile genetic elements vary greatly among organisms, and this variation accounts for the enormous range in genome size among organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.