ArticlePediatric discovery2025
Assessing early left ventricular remodeling in pediatric hypertension: A study using transthoracic echocardiography combined with two-dimensional speckle tracking echocardiography in an immature rabbit model.
Article in Pediatric discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explored the value of routine transthoracic echocardiography (TTE) combined with two-dimensional speckle tracking echocardiography (2D-STE) for the early evaluation of left ventricular remodeling in the hypertensive immature rabbit model. Twenty-seven New Zealand white rabbits were divided into Group A (sham-operated group), Group B (mild group), and Group C (severe group), with 9 rabbits per group. The hypertension model was constructed using the "two kidneys one clip" method. Changes in left ventricular function and the degree of left ventricular wall thickening were observed by TTE at 1, 4, and 8 weeks after modeling. The global longitudinal strain (GLS-AVG, GLS-A4C, GLS-A2C, and GLS-LAX) of the left ventricle (LV) and the longitudinal strain (LS) of the 18 segments of left ventricular myocardium were analyzed using 2D-STE. Concurrently, LV myocardial tissue was sampled for HE staining and Masson staining. Receiver operating characteristic (ROC) curves were plotted to evaluate the accuracy of 2D-STE parameters in predicting myocardial fibrosis. The model group exhibited varying degrees of left ventricular remodeling. GLS-A4C, GLS-A2C, GLS-LAX, and GLS-AVG in the model group increased at 1 week after modeling (
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