Evidence map›Paper›PMID 40626270›Full record

ReviewSmart molecules : open access2024

Recent advances in single fluorescent probes for monitoring dual organelles in two channels.

Xiu-Zhi Yang, Shankun Yao, Jisong Wu, Jiajie Diao, Weijiang He, Zijian Guo, Yuncong Chen

Abstract readReview
In one paragraph

Review in Smart molecules : open access, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiu-Zhi YangState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.
Shankun YaoState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.
Jisong WuState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.
Jiajie DiaoDepartment of Cancer Biology University of Cincinnati College of Medicine Cincinnati Ohio USA.
Weijiang HeState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.
Zijian GuoState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.
Yuncong ChenState Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center Nanjing University Nanjing China.ORCID https://orcid.org/0000-0002-8406-4866

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively visualizing the highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due to the distinct advantages of facile, non-invasiveness and dynamic detection, making it particularly well-suited for applications in uncovering the mysterious veil of organelle interactions. Regrettably, the lack of ideal fluorescence agents has always been an obstacle in imaging the intricate behaviors of organelles. In this review, we provide a systematic discussion on the existing dual-color and dual-targetable molecular sensors used in monitoring organelle interactions, with a specific focus on their targeting strategies, imaging mechanisms and biological applications. Additionally, the current limitations and future development directions of dual-targetable probes and dual-emissives are briefly discussed. This review aims to provide guidance for researchers to develop more improved probes for studying organelle interactions in the biomedical field.

Indexed as

bioimagingdual‐colordual‐targetedfluorescent probesorganelle interaction

Identifiers

PMID40626270
PMCPMC12118280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.