ArticleInternational journal of general medicine2025
A Risk Model Based on sCD25 for Early Mortality in Adult Patients with Hemophagocytic Lymphohistiocytosis.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory syndrome, is characterised by rapid disease progression and high early mortality. We aim to investigate the characteristics of the early death (ED) in adults with HLH and develop a reliable risk model to predict early mortality. Materials and Methods: Between September 2013 and July 2024, 254 adult patients with HLH were examined. Clinical data including presentation, triggers, treatments, and laboratory results were reviewed. Cases were randomly divided into training and validation cohorts using R. Independent risk factors for 60-day mortality were identified, leading to the development of a risk model using nomogram. Results: 26.4% (67/254) of patients with HLH died within 60 days. Cox multivariate analyses identified independent risk factors for 60-day mortality, including PLT <100×10 Conclusion: The novel ED risk model can effectively and precisely identify high-risk adult patients with HLH, offering appropriate clinical recommendations.
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