Evidence map›Paper›PMID 40626230›Full record

ArticleFrontiers in nutrition2025

The association between the dietary index for gut microbiota and its components with cardiovascular disease risk: a cross-sectional study based on NHANES.

Lin Na, Jing Chang, Xinqi Li, Xiaona Che, Yunfei Sun, Wenjing Cui, Xin Xue

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lin Na *Department of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Jing Chang *Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China.
Xinqi LiDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Xiaona CheDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Yunfei SunDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Wenjing CuiDepartment of Cardiology, Xi'an International Medical Center Hospital, Xi'an, China.
Xin XueDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cardiovascular disease (CVD) is a leading cause of mortality worldwide, and its development and progression are closely associated with diet-induced changes in gut microbiota. This study aims to investigate the relationship between the dietary index for gut microbiota (DI-GM) and its components, including the beneficial gut microbiota score (BGMS) and the unfavorable gut microbiota score (UGMS), in relation to cardiovascular disease. Methods: We conducted a cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data (1999-2020), collecting baseline sociodemographic and health-related data from 41,193 adults aged ≥20 years. We constructed multivariable weighted logistic regression models to evaluate associations between DI-GM, BGMS, UGMS, and CVD risk, generating weighted restricted cubic spline (RCS) plots to visualize dose-response relationships. Subgroup analyses assessed outcome robustness across sex, age, hypertension, and diabetes subgroups. Results: After adjusting for confounders (age, sex, race, poverty-to-income ratio [PIR index], marital status, and education level, smoking status, alcohol consumption, body mass index [BMI], and comorbidities), significant associations emerged between DI-GM, BGMS, and CVD risk. Increasing DI-GM and BGMS levels showed gradually decreasing CVD risk trends (DI-GM: OR = 0.97, 95% CI: 0.94-1.00, Conclusion: Among adults aged ≥20 years, DI-GM and BGMS showed significant inverse association with CVD risk. Compared to DI-GM, BGMS demonstrates a stronger inverse association with cardiovascular disease risk. These findings underscore the potential crucial role of favorable dietary patterns in cardiovascular disease prevention.

Indexed as

cardiovascular diseasedietary indexdietary patterngut microbiotaNHANES

Identifiers

PMID40626230
PMCPMC12231476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.