Evidence map›Paper›PMID 40626213›Full record

ArticleBeilstein journal of organic chemistry2025

High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters.

Kelsey Plasse, Valerie Wright, Guoshu Xie, R Bernadett Vlocskó, Alexander Lazarev, Béla Török

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kelsey PlasseDepartment of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, USA.
Valerie WrightDepartment of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, USA.
Guoshu XieDepartment of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, USA.
R Bernadett VlocskóDepartment of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, USA.
Alexander LazarevPressure BioSciences Inc., 480 Neponset Street, Unit 10B, Canton, MA, USA.ORCID https://orcid.org/0009-0005-1490-9025
Béla TörökDepartment of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, USA.ORCID https://orcid.org/0000-0002-5465-9789

Funding

Green Synthesis of Building Blocks and APIs by High Hydrostatic Pressure-initiated SynthesisR15GM157702 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI TOROK, BELA · 2024 to 2024
$458k
NIGMS NIH HHS R15 GM157702
6 · The paper itself

Abstract

High hydrostatic pressure (HHP) was found to be an efficient activation method in several catalyst- and solvent-free reactions and has found application for the syntheses of heterocycles and the preparation of active pharmaceutical ingredients (APIs) via acylation and acid- and solvent-free esterification. The reactions were carried out at ambient pressure (control) and under HHP (up to 3.8 kbar) conditions. These representative reactions provided higher yields for the products and HHP enabled truly green processes that are catalyst- and solvent-free, to occur with high yields and producing only non-toxic by-products. A computational study accompanies the experimental data to interpret the outcome of the reactions.

Indexed as

acetaminophenacetylsalicylic acidbenzimidazolescatalyst-free synthesiscyclizationestershigh hydrostatic pressurepyrazoles

Identifiers

PMID40626213
PMCPMC12230333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.