Evidence map›Paper›PMID 40626170›Full record

ArticleFrontiers in transplantation2025

Hypomethylating therapy mitigates acute allograft rejection in a murine lung transplant model.

Kristine M Yarnoff, William N Daccarett-Bojanini, Andres F Villabona-Rueda, Manuel Sollmann, Franco R D'Alessio, Jeffrey M Dodd-O

Abstract read
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In one paragraph

Article in Frontiers in transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristine M Yarnoff *Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.
William N Daccarett-Bojanini *Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.
Andres F Villabona-RuedaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.
Manuel SollmannDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.
Franco R D'AlessioDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.
Jeffrey M Dodd-ODepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institution, Baltimore, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Acute cellular rejection of transplanted lung allografts involves activated cytotoxic T cells and reduced Regulatory T (Treg) cell function. Calcineurin inhibitors, the cornerstone of immunosuppressive regimens, suppress T cell cytotoxicity but inhibit Treg proliferation. The DNA hypomethylating agent decitabine (DAC) can abrogate T cell cytotoxicity while stimulating Treg proliferation. Methods: We sought to determine the effects of DAC treatment in a murine MHC-mismatched orthotopic lung transplant model. Results: Rescue treatment with DAC maintains lung allograft gross and histologic integrity with a reduction in cytotoxic T cell responses. CD4+FoxP3+ T cell depletion in Foxp3DTR mice exacerbated rejection lung injury compared to CD4+FoxP3+ T cell sufficient mice and failed to abolish the protective effect of DAC in this model. The protective effect of DAC was associated with a reduction in cytokine production from host T-cells. Discussion: Decitabine could offer a new line of treatment for acute lung allograft rejection, in part via its effects on Tregs.

Indexed as

acute rejectiondecitabineimmune tolerancelung transplantationT regulatory cells

Identifiers

PMID40626170
PMCPMC12230056

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.