Article in Pediatric discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Bei TongChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Junyan YanChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Zhujun SunChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Ruifang LuoChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Fang LinChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Riqiang HuChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Ting YangChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Yuting WangChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.
Jie ChenChildren Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Chongqing China.ORCID https://orcid.org/0000-0002-3170-8525
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
DNA methylation is widely involved in the modification of intestinal function, but the methylation mechanism in the enteric nervous system has not been studied in vitamin A deficiency (VAD). Herein, we firstly found that in the VAD group, gastrointestinal transit time was delayed compared with the vitamin A normal (VAN) group. RNA sequencing between VAD and VAN rats identified enriched pathways associated with enteric nerves and methylation transferase complexes. Then expression levels of DNA methyltransferases (DNMT1, DNMT3a and DNMT3b) were validated to significant increase in the VAD group. Representative reduced bisulfate sequencing showed that the VAD rats had high levels of DNA methylation in promoters and exons compared with the VAN rats. A combined methylomic and transcriptomic analysis identified that methylation levels of
Indexed as
enteric neuronsmethylationSGK1/FOXO pathwayvitamin A deficiencyvitamin A supplementation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Vitamin A deficiency triggers colonic methylation potentially impairing colonic neuron via downregulation SGK1/FOXO pathway. · full record | OpenQuestion