Evidence map›Paper›PMID 40626090›Full record

ArticleJCEM case reports2025

Prolactinoma Resection in a Transgender Woman on Gender-affirming Hormone Therapy.

Zachary C Gersey, Andres F Vargas, Janet H Leung, Pouneh K Fazeli, Georgios A Zenonos, Paul A Gardner

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary C GerseyDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID https://orcid.org/0000-0002-4353-0779
Andres F VargasDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Janet H LeungDivision of Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Pouneh K FazeliNeuroendocrinology Unit, Division of Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Georgios A ZenonosDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Paul A GardnerDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID https://orcid.org/0000-0002-1594-1722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of prolactinoma in the setting of gender-affirming hormone therapy (GAHT) is lacking in the literature. We present the case of a transgender woman who was found to have prolactinoma prior to initiating GAHT. Initially, medication effectively managed prolactin levels; however, upon starting GAHT, maintaining control of these levels became challenging. Opting to sustain GAHT without disruption and gain control over symptomatic hyperprolactinemia, the patient underwent endoscopic endonasal surgery, resulting in gross total tumor resection including the medial wall of the cavernous sinus. Postoperative assessments revealed normal prolactin levels without dopamine agonist medication, allowing uninterrupted continuation of GAHT; in the following months, prolactin has minimally increased with plans for monitoring without treatment for now due to intolerance of oral antidopaminergics and lack of visible lesion on follow-up magnetic resonance imaging.

Indexed as

endoscopic endonasal surgerygender transition careprolactinomatransgender

Identifiers

PMID40626090
PMCPMC12230653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.