ReviewRSC advances2025
Mechanistic insights and therapeutic innovations in engineered nanomaterial-driven disruption of biofilm dynamics.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.Virulence · 2026Review
- Smart Mesoporous Silica Nanoparticle-Based Drug Delivery Systems: Recent Advances in Biomedical Applications, Wound Healing and Therapeutic Perspectives.Pharmaceutics · 2026Review
- Bioactive Hydrogel-MOF Composites as Resistance-Modulating Wound Interfaces: Molecular Mechanisms and Rational Design for Chronic Wound Management.Gels (Basel, Switzerland) · 2026Review
- Piperazine linked chitosan schiff base nanoparticles as a novel antibiofilm and antibacterial strategy against clinically relevant pathogens.Scientific reports · 2026Article
- Hibiscus derived nitrogen doped carbon nanochains for visual pH sensing and catalytic methyl orange degradation.Scientific reports · 2026Article
- Smart Nano-Antibiotics: AI-Guided Stimuli-Responsive Nanoplatforms for Precision Antimicrobial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Antimicrobial nanomaterials at the nanoscale: design principles, mechanisms, and global challenges.Nanoscale advances · 2026Review
- An inhalable dry powder co-delivery system of ciprofloxacin liposomes and S-nitrosoglutathione for synergistic treatment of Pseudomonas aeruginosa biofilm-associated pulmonary infections.Drug delivery and translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria employ biofilm formation as a survival strategy, characterized by the self-assembly of cells into 3D architectures encapsulated in an extracellular polymeric substance (EPS) that results in reduced antibiotic efficacy, increased tolerance, and emergence of multidrug resistance phenotypes. To overcome this challenge, persistent efforts are directed toward developing cutting-edge approaches and agents that rejuvenate antibiotic efficacy, mitigate biofilm formation, and eradicate biofilm-associated bacterial infections. Within this framework, nanotechnology has emerged as a pivotal tool for developing innovative functional materials with tailored attributes, exhibiting substantial potential in addressing the global health challenge of antibiotic resistance and biofilm-associated infections. This updated review article provides a comprehensive overview, commencing with a thorough analysis of biofilm formation and its implications, followed by a critical evaluation of cutting-edge strategies derived from recent research advancements. Our discussion encompasses novel strategies, including traditional nanomaterials, micro-nanobubbles, multifunctional nanozyme-mimetic platforms, artificial phage-like structures, and sophisticated nano-microrobotic systems. Each strategy is assessed for its potential to effectively target biofilms, enhance antimicrobial penetration, and restore antibiotic susceptibility. We anticipate that this timely review will inform and inspire innovative research directions, focusing on the rational design and application of advanced nanomaterials for targeted biofilm modulation and efficacious treatment, thereby advancing healthcare solutions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.