ReviewFrontiers in physiology2025
Circadian influences on central nervous system barriers and the glymphatic system.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.Molecular neurobiology · 2026Review
- Deep cervical lymphatic-venous anastomosis in dementia: a clinical and mechanistic evaluation.International journal of surgery (London, England) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provided by these systems has broad implications for many physiological processes and several pathological conditions are associated with their disruption. Recent studies support the notion that CNS barriers and fluids are regulated by circadian rhythms. Whereas reciprocal associations between the structural and functional integrity of neural barriers and disease states are well-established, the role of circadian rhythms in mediating these relationships remains unspecified. The goals of this review are to provide a general overview of three primary systems responsible for maintaining CNS homeostasis, namely the blood-brain barrier, blood-cerebrospinal fluid barrier, and glymphatic system, and to synthesize recent evidence highlighting the role of circadian rhythms as a critical regulator of CNS fluid and barrier function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.