Evidence map›Paper›PMID 40626041›Full record

ReviewBioinformatics advances2025

Perspective on recent developments and challenges in regulatory and systems genomics.

Julia Zeitlinger, Sushmita Roy, Ferhat Ay, Anthony Mathelier, Alejandra Medina-Rivera, Shaun Mahony, Saurabh Sinha, Jason Ernst

Abstract readReview
In one paragraph

Review in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. AlphaGenome Atlas:medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia ZeitlingerStowers Institute for Medical Research, Kansas City, MO 64112, United States.
Sushmita RoyDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53715, United States.
Ferhat AyCenters for Autoimmunity, Inflammation and Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA 92037, United States.ORCID https://orcid.org/0000-0002-0708-6914
Anthony MathelierNorwegian Centre for Molecular Biosciences and Medicine (NCMBM), Nordic EMBL Partnership, University of Oslo, Oslo 0318, Norway.ORCID https://orcid.org/0000-0001-5127-5459
Alejandra Medina-RiveraLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro 76230, Mexico.ORCID https://orcid.org/0000-0002-7912-2718
Shaun MahonyCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.ORCID https://orcid.org/0000-0002-2641-1807
Saurabh SinhaWalter H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States.
Jason ErnstDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID https://orcid.org/0000-0003-4026-7853

Funding

Leveraging genetic variation to dissect gene regulatory networks of reprogramming to pluripotencyU01HG012079 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Chongyuan Luo, Kathrin Plath · 2021 to 2026
$6.9M
Studying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6M
Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brainsU01MH130995 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Chongyuan Luo, Mercedes Paredes · 2022 to 2026
$4.4M
Understanding the predeterminants of transcription factor regulatory activityR35GM144135 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Shaun Aengus Mahony · 2022 to 2026
$2.4M
Deciphering the Relationship between Substance Use and Psychiatric Disorders from Whole Genome Sequencing DataDP1DA044371 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ERNST, JASON · 2017 to 2021
$2.3M
Quantitative Regulatory Genomics: Networks, CIS-Regulatorycodes, and Phenotypic VariationR35GM131819 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SINHA, SAURABH · 2019 to 2023
$1.8M
Defining gene regulatory networks controlling cell fateR01GM144708 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ROY, SUSHMITA · 2022 to 2025
$1.3M
NHGRI NIH HHS U01 HG012079NIDA NIH HHS DP1 DA044371NIGMS NIH HHS R01 GM144708NIGMS NIH HHS R35 GM128938NIGMS NIH HHS R35 GM131819NIGMS NIH HHS R35 GM144135NIMH NIH HHS U01 MH130995
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40626041
PMCPMC12233095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.