ArticleJournal of inflammation research2025
The Prognostic Value of Platelet-to-Lymphocyte Ratio and Tricuspid Regurgitation Velocity in Patients with Light-Chain Myocardial Amyloidosis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To explore the prognostic value of inflammatory indexes and novel echocardiographic parameters in light-chain myocardial amyloidosis (AL-CA) patients. Methods: We retrospectively collected clinical, laboratory, electrocardiography and echocardiographic parameters of patients. The prognostic value of inflammation indexes and echocardiographic parameters was assessed, and the association of inflammation indexes with cardiac function and the type of light chain (AL) was analyzed. Results: In total, 83 biopsy-proven AL-CA patients were studied (age: 61.42±10.7 years; 68.7% male). The inflammation indexes [PLR (Platelet-to-Lymphocyte ratio), NLR (Neutrophil-to-Lymphocyte ratio), NMLR ((Neutrophil+Monocyte)-to-Lymphocyte ratio), SIRI ((Monocyte × Neutrophil)-to-Lymphocyte ratio), SII ((Platelet × Neutrophil)-to-Lymphocyte ratio), (all P<0.001)] and echocardiographic parameter TRV (Tricuspid Regurgitation Velocity), (P=0.005) were significantly higher in deceased patients compared with survivors. Multivariate COX regression analysis indicated that PLR, TRV, Lymphocyte (LYM) and Left Ventricular Ejection Fraction (LVEF) were independent outcome predictors. The PLR, TRV, and the combined indicator (PLR+TRV) showed great value in predicting short-term prognosis. The likelihood ratio χ2 test showed that PLR and TRV added predictive values to the Mayo04, Mayo12, and Euro15 models. The Spearman correlation analysis demonstrated a positive correlation between the inflammation indexes and New York Heart Association (NYHA) class, Mayo04 stage, Mayo12 stage, and Euro15 stage. Additionally, the NLR (P<0.001), NMLR (P=0.002), SIRI (P=0.029), and SII (P<0.001) were higher in Lambda than in Kappa light-chain patients. Conclusion: Our study revealed that PLR and TRV were valid predictors of short-term survival in AL-CA, and the levels of several inflammation indexes correlated with the severity of cardiac involvement and AL subtype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.