Evidence map›Paper›PMID 40626014›Full record

ReviewFrontiers in oncology2025

Part I: consensus statements and expert recommendations for

Soo Chin Lee, Yeon Hee Park, Christian F Singer, Judith Balmaña, Rebecca Alexandra Dent, Veronique Kiak-Mien Tan, Nadia Ayu Mulansari, Mastura Md Yusof, Frances Victoria F Que, Yen-Shen Lu and 6 more

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Soo Chin LeeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Yeon Hee ParkDivision of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Christian F SingerDepartment of Obstetrics and Gynaecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Judith BalmañaDepartment of Medical Oncology, University Hospital Campus Vall Hebron, Barcelona, Spain.
Rebecca Alexandra DentDivision of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
Veronique Kiak-Mien TanDivision of Surgery and Surgical Oncology, Department of Breast Surgery, National Cancer Centre Singapore, Singapore, Singapore.
Nadia Ayu MulansariHaematology-Medical Oncology Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital/Universitas Indonesia, Jakarta, Indonesia.
Mastura Md YusofPicaso Cancer Centre, Hospital Picaso, Petaling Jaya, Selangor, Malaysia.
Frances Victoria F QueDepartment of Internal Medicine and Oncology, St Luke's Medical Center, Quezon City and Global City, Metro Manila, Philippines.
Yen-Shen LuDepartment of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Napa ParinyanitikulMedical Oncology Unit, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Cam Phuong PhamNuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
Nur Aishah TaibDepartment of Surgery, Faculty of Medicine, University Malaya, UM Cancer Research Institute, Kuala Lumpur, Malaysia.
Sun-Young KongDepartment of Laboratory Medicine and Genetic Counselling Clinic, National Cancer Center, Goyang, Republic of Korea.
Yoland AntillFamilial Cancer Centre, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Hee Jeong KimDivision of Breast Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In the Asia-Pacific region, there is increasing contention on the practical challenges involved in managing human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (eBC). This modified Delphi consensus explores gaps in genetic counselling (GC) and genetic testing (GT), and clinical risk assessment for Methods: An expert panel of 16 Asia-Pacific medical oncologists, geneticists, and breast cancer surgeons arrived at 33 statements. The level of statement consensus was considered high at ≥75%. A survey of 134 healthcare practitioners (HCPs) (breast cancer surgeons, geneticists, oncologists, molecular biologists/pathologists) explored the real-world practices in this region. Results: A consensus was reached for 88% of the statements (29/33) and aligned with international guidelines. Experts reached 100% consensus on offering pretest GC, obtaining consent before GT, considering first diagnosis of breast cancer (BC) as ideal time for GT, offering reflex testing for patients with likely/pathogenic germline Conclusion: GT and pretest GC should be mainstreamed at the first diagnosis of BC. Risk assessment for disease recurrence should be performed at diagnosis and post-surgery for

Indexed as

BRCA germline pathogenic variantsconsensusearly breast cancerHER2HR+recurrencetriple-negative breast cancer

Identifiers

PMID40626014
PMCPMC12230085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.