ArticleFrontiers in oncology2025
CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Human immunosuppressive neutrophils: recent answers to old and new questions.The EMBO journal · 2026Review
- Writers and readers of sialylation in immunoregulation in cancer.The Journal of biological chemistry · 2026Review
- Integration of Mendelian randomization and transcriptome wide association studies for causal gene identification in ovarian cancer genetic architecture.Discover oncology · 2025Article
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Authors and funding
7 authors.
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Abstract
Background: Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mediate cancer immune suppression by promoting an immunosuppressive microenvironment that inhibits effective anti-tumor immunity. However, they are still a poorly understood, heterogeneous mix of neutrophil subsets. This study aims to determine the Siglec expression profile on several neutrophil subsets and assess their immunosuppressive ability. Methods: We identified CD16 Results: Two distinct subpopulations were investigated within the low-density fraction of human peripheral blood (CD15 Conclusions: These results demonstrate that Siglecs are differentially expressed on neutrophil subsets, and along with CD16, may be used to help further define what is a PMN-MDSC. Consistent with current observations by others, PMN-MDSCs may encompass an array of neutrophil subtypes, including low-density neutrophils, and point to the need for more work to precisely define the genetic signatures of PMN-MDSCs.
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