Evidence map›Paper›PMID 40625924›Full record

ArticlePeerJ2025

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase.

Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T Matkarimov, Dmitry Zharkov, Murat K Saparbaev, Sabira Taipakova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana ManapkyzyScientific Research Institute of Biology and Biotechnology Problems, Al-Farabi Kazakh National University, Almaty, Kazakhstan.ORCID 0000-0003-3371-4459
Gulzhan ZhamanbayevaScientific Research Institute of Biology and Biotechnology Problems, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Viktoriya SidorenkoDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, United States.
Radha BonalaDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, United States.
Francis JohnsonDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, United States.
Bakhyt T MatkarimovL. N. Gumilev Eurasian National University, Astana, Kazakhstan.ORCID 0000-0003-0775-7324
Dmitry ZharkovDepartment of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia.ORCID 0000-0001-5013-0194
Murat K SaparbaevDepartment of Molecular Biology and Genetics, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Sabira TaipakovaScientific Research Institute of Biology and Biotechnology Problems, Al-Farabi Kazakh National University, Almaty, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Consumption of aristolochic acids (AA) from the plant Methods: In the present work, using Results: We have demonstrated that TDG either does not excise thymine or does so with extremely low efficiency when it is paired with dA-AL or dG-ALII adducts in duplex DNA. At the same time, TDG excises with high efficiency thymine opposite to guanine and hypoxanthine in T•G and T•Hx mispairs. Discussion: These findings strongly suggest that the human TDG is not involved in the aberrant DNA repair of AA-induced DNA damage.

Indexed as

Aristolochic AcidsDNADNA AdductsThymineThymine DNA GlycosylaseDNA DamageDNA RepairHumansAristolochic AcidsDNADNA AdductsThymineThymine DNA GlycosylaseAberrant DNA repairAristolactam-adenine adductAristolactam-guanine adductAristolochic acidBase excision repairDNA glycosylaseDNA repairMutational signatureThymine-DNA glycosylaseT to A transversions

Identifiers

PMID40625924
PMCPMC12232928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.