Evidence map›Paper›PMID 40625909›Full record

ArticleSmart molecules : open access2024

"Crossbreeding" NIR-II flavchromene for PSMA-positive prostate cancer detection and image-guided surgery.

Jialiang Huang, Yongkang Yao, Liao Zhang, Chenxu Yan, Zhiqian Guo

Abstract read
PubMed Full text at PMC Publisher
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Article in Smart molecules : open access, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jialiang HuangState Key Laboratory of Bioreactor Engineering, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Yongkang YaoState Key Laboratory of Bioreactor Engineering, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Liao ZhangState Key Laboratory of Bioreactor Engineering, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Chenxu YanState Key Laboratory of Bioreactor Engineering, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Zhiqian GuoState Key Laboratory of Bioreactor Engineering, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0000-0002-2192-825X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) is known to be overexpressed in prostate cancer (PCa). The development of precise and rapid imaging technologies to monitor PSMA is crucial for early diagnosis and therapy. Fluorescence imaging in the second near-infrared window (NIR-II) has emerged as a powerful tool for real-time tracking and in vivo visualization, offering high sensitivity and resolution. However, there is a lack of stable, bright and easy-to-implement NIR-II fluorescent probes for PSMA targeting. Herein, we presented a PSMA-targeting NIR-II fluorescent probe FC-PSMA based on π-conjugated crossbreeding dyed strategy that affords high stability, large extinction coefficient, and good brightness. As demonstrated, FC-PSMA displayed a high fluorescence quantum yield in fetal bovine serum (FBS). Following intravenous injection of FC-PSMA, the tumor-to-normal ratio of fluorescence intensity steadily increased over time, reaching a peak at 48 h (tumor-to-leg ratio = 12.16 ± 0.90). This advancement enables precise identification of PC through NIR-II fluorescence imaging, facilitating high-performance guidance for prostate cancer resection surgery.

Indexed as

fluorescence dyesnear‐infraredNIR‐II fluorescence imagingPSMA‐targeting

Identifiers

PMID40625909
PMCPMC12118234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.