Evidence map›Paper›PMID 40625849›Full record

ArticleLife metabolism2025

Liver ERα mediates sex differences in metabolic pattern changes in response to time-restricted feeding.

Haoqi Zhang, Tengteng Huang, Xianyang Jin, Siyuan Liu, Yi Yang, Luting Liu, Xuemei Jiang, Ruinan Zhang, Hui Ye, Xinyue Qi and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Haoqi ZhangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Tengteng HuangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Xianyang JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Siyuan LiuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yi YangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Luting LiuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Xuemei JiangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Ruinan ZhangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Hui YeSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore.
Xinyue QiSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore.
Tongxing SongCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Chao JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Bin FengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.ORCID https://orcid.org/0000-0001-6258-2729
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Zhengfeng FangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Ting LuoState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
De WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.ORCID https://orcid.org/0000-0002-8348-4199
Lun HuaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.ORCID https://orcid.org/0009-0000-6816-5192

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Time-restricted feeding (TRF) is a dietary strategy used to prevent and treat obesity in both sexes. However, TRF affects liver metabolism differently in males and females, and the mechanisms behind these differences remain unclear. Our study reveals that during TRF, female livers are more likely to break down amino acids (AAs) to synthesize fats, while male livers significantly reduce fatty acid synthesis. The changes in the liver's AA metabolic profile after gonadectomy suggest that estrogen signaling is crucial for regulating AA metabolism in females during TRF. Additionally, we demonstrate that hepatic estrogen receptor α (ERα)-mediated AA metabolism contributes to the sex-specific effects of TRF on liver metabolism. These findings offer new insights into the molecular mechanisms of TRF and its potential clinical application for treating fatty liver and other metabolic disorders. They also emphasize the need to consider sex differences when developing nutritional and pharmacological treatments for metabolic diseases in females.

Indexed as

estrogen receptor αliver metabolismsexual dimorphismtime-restricted feeding

Identifiers

PMID40625849
PMCPMC12230693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.