Evidence map›Paper›PMID 40625797›Full record

ReviewBurns & trauma2025

Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.

Jiahui Song, Zhengchao Yuan, Xiao Yu, Yihong Shen, Jinglei Wu, Binbin Sun, Cheng Xue Qin, Mohamed El-Newehy, Xiumei Mo, Hongbing Gu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiahui SongSchool of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, No. 888 Caolang Road, Jinshan District, Shanghai 201514, P.R. China.
Zhengchao YuanState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.
Xiao YuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.
Yihong ShenState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.
Jinglei WuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.
Binbin SunState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.
Cheng Xue QinDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.ORCID https://orcid.org/0000-0003-2169-2686
Mohamed El-NewehyDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Xiumei MoSchool of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, No. 888 Caolang Road, Jinshan District, Shanghai 201514, P.R. China.ORCID https://orcid.org/0000-0001-9238-6171
Hongbing GuDepartment of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 Xinsongjiang Road, Songjiang District, Shanghai 201600, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury results in sensory and motor dysfunction, which is an enormous economic burden for patients and society. Complete recovery of peripheral nerve function after injury is complicated. Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest. Electroactive biomaterials induce an active state of electrical stimulation (ES) at the site of peripheral nerve injury when incorporated into nerve guidance channels. Numerous studies have demonstrated that combining ES with electroactive biomaterials can enhance peripheral nerve repair. This review summarizes the regulation of signal pathways by ES and the functions of various electroactive biomaterials, including metals, carbon-based materials, conductive polymers, and piezoelectric materials. Recent advances and research of ES combined with electroactive biomaterials in peripheral nerve repair are reviewed, which may help to come up with more effective strategies to restore neural function after PNI.

Indexed as

Electrical stimulationElectroactive biomaterials, Peripheral nerve regenerationPeripheral nerve injury

Identifiers

PMID40625797
PMCPMC12232428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.