Rationalizing the Influence of Solvent on the Nucleation of Griseofulvin through Classical and Nonclassical Pathways.

Mariana O Diniz, Harsh Barua, Jennifer Cookman, Michael Svärd, Åke Rasmuson, Sarah P Hudson

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In one paragraph

Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariana O DinizSSPC the Research Ireland Centre for Pharmaceuticals, Department of Chemical Sciences, and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.

Harsh BaruaSSPC the Research Ireland Centre for Pharmaceuticals, Department of Chemical Sciences, and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.

Jennifer CookmanSSPC the Research Ireland Centre for Pharmaceuticals, Department of Chemical Sciences, and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0002-7054-7322

Michael SvärdDepartment of Chemical Engineering, KTH Royal Institute of Technology, Stockholm SE-10044, Sweden.ORCID https://orcid.org/0000-0002-6647-3308

Åke RasmusonSSPC the Research Ireland Centre for Pharmaceuticals, Department of Chemical Sciences, and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0003-1790-2310

Sarah P HudsonSSPC the Research Ireland Centre for Pharmaceuticals, Department of Chemical Sciences, and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0002-6718-2190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of solvent on active pharmaceutical ingredient (API) nucleation behavior is system-dependent. A better understanding of the role of the solvent in nucleation could help predict and control crystallization. In this work, induction time experiments, spectroscopic analysis, and dynamic light scattering were used to explore the influence of solvent on the polymorphic landscape and the nucleation behavior of griseofulvin (GSF), a medium-sized, flexible, model API. Based on a total of 2960 induction time experiments, the relative ease of nucleation was characterized in three solvents commonly used in the pharmaceutical industry: methanol (MeOH), acetonitrile (ACN), and

Identifiers

PMID40625785

DOI10.1021/acs.cgd.5c00206

PMCPMC12232334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.