Evidence map›Paper›PMID 40625768›Full record

ArticleInternational cancer conference journal2025

Diagnostic and clinical challenges of primary pulmonary solid adenocarcinoma with signet-ring cell features: a case report with unusual presentation and literature review.

Noura A A Ebrahim, Moamen O Othman, Ahmed M Fahmy, Neveen S Tahoun, Rasha A Salama, Nermeen Mostafa Mahmoud, Habiba Elfandy

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PubMed Full text at PMC Publisher
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Article in International cancer conference journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noura A A EbrahimOncologic Pathology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.ORCID 0009-0001-7037-680X
Moamen O OthmanKasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed M FahmyOncologic Pathology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.
Neveen S TahounOncologic Pathology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.
Rasha A SalamaKasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Nermeen Mostafa MahmoudMedical Oncology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.
Habiba ElfandyOncologic Pathology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid adenocarcinoma with signet-ring cell features (SRCF) is an extremely rare variant of lung adenocarcinoma, often mimicking metastatic tumors from other sites. Accurate diagnosis relies heavily on immunohistochemical profiling. This report discusses a case of solid adenocarcinoma with SRCF presenting with pleural thickening, highlighting diagnostic challenges and treatment limitations. We report a 36-year-old smoker with progressive dyspnea and pleuritic pain. Imaging revealed pleural thickening and pulmonary nodules. Histopathology showed solid adenocarcinoma with SRCF, confirmed by immunohistochemistry as primary pulmonary signet-ring cell carcinoma (SRCC). Despite chemotherapy, the disease progressed, and the patient succumbed within 3 months. Primary pulmonary solid adenocarcinoma with SRCF is associated with high mortality and diagnostic complexity. Immunohistochemical markers remain pivotal in establishing its pulmonary origin. This case reinforced the urgent need for better diagnostic techniques and therapies. Graphical abstract:

Indexed as

Adenocarcinoma with SRCFAggressive tumorImmunohistochemistryPleural thickeningPrecision diagnosis

Identifiers

PMID40625768
PMCPMC12229407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.