ArticleInternational cancer conference journal2025
Bilateral osteonecrosis of the external auditory canal caused by bone-modifying agents for cancer bone metastases.
Article in International cancer conference journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Medication-related osteonecrosis of the external auditory canal and treatment with teriparatide.JCEM case reports · 2026Article
- A predictive nomogram for treatment response in osteonecrosis patients receiving denosumab with UKA: integrating bone turnover markers and functional parameters.Endocrine connections · 2025Article
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7 authors.
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Abstract
A 51-year-old woman with a 54-month history of treatment with bone-modifying agents for thyroid cancer bone metastases, namely zoledronic acid for three months and denosumab for 51 months, presented with jaw pain, trismus, and ear discharge. Physical examination, bacterial culture, and radiological findings led to a diagnosis of osteonecrosis of the external auditory canal. Since the discontinuation of denosumab did not improve the diagnosed condition, she underwent surgical reconstruction. Bone-modifying agents such as zoledronic acid and denosumab, which are commonly used to prevent skeletal-related events in patients with bone metastases from various cancers, have been used for several years, especially for patients with slow-growing cancers. Osteonecrosis of the external auditory canal is an infrequent but serious adverse event caused by prolonged use of bone-modifying agents. Therefore, clinicians should be fully aware of its potential risks in the long-term management of bone metastasis.
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