Evidence map›Paper›PMID 40625738›Full record

ReviewFrontiers in immunology2025

From syndromic clues to diagnosis: understanding CARD11-driven disorders.

Elena García-Martínez, María Teresa Schiaffino, Marisa Di Natale, María de Las Mercedes Díaz Luna, Daniel Alejandro Viteri Álvarez, María Alejandra Mejía González

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Emerging Paediatric Uses of Dupilumab Beyond Approvals.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elena García-MartínezServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
María Teresa SchiaffinoServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Marisa Di NataleServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
María de Las Mercedes Díaz LunaServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Daniel Alejandro Viteri ÁlvarezServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
María Alejandra Mejía GonzálezServicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CARD11 is primarily expressed in hematopoietic tissues and lymphocytes and plays a crucial role in the proper activation of B and T cells in response to antigen recognition. Pathogenic variants in the

Indexed as

CARD Signaling Adaptor ProteinsGuanylate CyclaseImmunologic Deficiency SyndromesAnimalsGenetic Predisposition to DiseaseHumansMutationCARD11 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseBENTACADINSCARD11germline mutationsinborn-errors-of-immunitysyndromic immunodeficiencies

Identifiers

PMID40625738
PMCPMC12229871

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.