Evidence map›Paper›PMID 40625731›Full record

ReviewFrontiers in immunology2025

The tumor microenvironment across four dimensions: assessing space and time in cancer biology.

Christina R Larson, Ayushi Mandloi, Satwik Acharyya, Julienne L Carstens

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christina R Larson *Department of Medicine, Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Immunology Institute, University of Alabama at Birmingham, Birmingham, AL, United States.
Ayushi Mandloi *Department of Medicine, Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Immunology Institute, University of Alabama at Birmingham, Birmingham, AL, United States.
Satwik AcharyyaDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States.
Julienne L CarstensDepartment of Medicine, Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Immunology Institute, University of Alabama at Birmingham, Birmingham, AL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment is heterogeneous, structurally complex, and continually evolving, making it difficult to fully capture. Common dissociative techniques thoroughly characterize the heterogeneity of cellular populations but lack structural context. The recent boom in spatial analyses has exponentially accelerated our understanding of the structural complexity of these cellular populations. However, to understand the dynamics of cancer pathogenesis, we must assess this heterogeneity across space and time. In this review, we provide an overview of current dissociative, spatial, and temporal analysis strategies in addition to existing and prospective spatiotemporal techniques to illustrate how understanding the tumor microenvironment, focusing on dynamic immune-cancer cell interactions, across four dimensions will advance cancer research and its diagnostic and therapeutic applications.

Indexed as

NeoplasmsTumor MicroenvironmentAnimalsCell CommunicationHumansSpatio-Temporal Analysisintravital imagingspatial omicsspatiotemporaltemporal analysistumor evolutiontumor immune microenvironmenttumor microenvironment

Identifiers

PMID40625731
PMCPMC12230089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.