Evidence map›Paper›PMID 40625715›Full record

ArticlePediatric discovery2023

Establishment and identification of cardiomyocyte arhGEF18 gene conditional knockout mice.

Kun Wan, Wenjing Yuan, Tiewei Lv

Abstract read
In one paragraph

Article in Pediatric discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kun WanDepartment of Cardiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Key Laboratory of Child Development and Disorders of Ministry of Education Chongqing Key Laboratory of Pediatrics Chongqing China.ORCID https://orcid.org/0009-0001-5682-985X
Wenjing YuanDepartment of Cardiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Key Laboratory of Child Development and Disorders of Ministry of Education Chongqing Key Laboratory of Pediatrics Chongqing China.
Tiewei LvDepartment of Cardiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Key Laboratory of Child Development and Disorders of Ministry of Education Chongqing Key Laboratory of Pediatrics Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Left ventricular noncompaction (LVNC) is a heterogeneous disorder with unclear genetic causes. The arhGEF18 gene is a guanine nucleotide exchange factor related to the Rho pathway and a possible predisposing gene for LVNC. In this study, a mouse model of arhGEF18 gene conditional knockout (cKO) in cardiomyocytes was established using the Cre-LoxP system to provide an animal model for the genetic study of LVNC. ArhGEF18 cKO mice were obtained by crossing arhGEF18

Indexed as

arhGEF18conditional knockoutCre/Loxpleft ventricular noncompaction

Identifiers

PMID40625715
PMCPMC12118263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.