Evidence map›Paper›PMID 40625690›Full record

ArticleToxicology research2025

Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice.

Qiangbing Yin, Junling Liu, Wenting Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qiangbing YinDepartment of Occupational and Environmental Health, Shenzhen Luohu District Center for Disease Control and Prevention, Block 2, Zhifeng Building, No. 112, Qingshuihe 1st Road, Luohu District, Shenzhen 518000, China.
Junling LiuDepartment of Health Monitoring Management, Shenzhen Futian District Center for Disease Control and Prevention, No. 8043, Hongli West Road, Futian District, Shenzhen 518000, China.
Wenting FengDepartment of Occupational Health Surveillance, Shenzhen Prevention and Treatment Center for Occupational Diseases, No. 2019, Buxin Road, Luohu District, Shenzhen 518000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2-Dichloroethane (1,2-DCE) is a widely used industrial solvent known to exert neurotoxic effects upon exposure. Hsp90 inhibition has emerged as a potential therapeutic strategy to mitigate neuroinflammation by targeting the NLRP3 inflammasome. However, its role in mitigating 1,2-DCE-induced neurotoxicity remains unclear. This study aimed to elucidate the neuroprotective effect of the Hsp90 inhibitor 17-AAG against 1,2-DCE-induced neurotoxicity and to elucidate the underlying mechanism involving NLRP3 inflammasome activation. Forty male CD-1 mice were exposed to 1,2-DCE (0, 100, 350, 700 mg/m

Indexed as

1,2-Dichloroethanecognitive impairmentHsp90neurotoxicityNLRP3 inflammasome

Identifiers

PMID40625690
PMCPMC12229088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.