ArticleCureus2025
Tracheoesophageal Fistula Following Chemoradiation and Esophagectomy in Esophageal Adenocarcinoma: A Fatal Complication.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tracheoesophageal fistula (TEF) is a rare but devastating complication that can arise in patients with esophageal cancer following multimodal therapy. We present the case of a 45-year-old male with stage III esophageal adenocarcinoma treated with neoadjuvant chemoradiation, followed by esophagectomy and immunotherapy. He subsequently developed a large TEF, resulting in recurrent aspiration, bleeding, and ultimately death despite comprehensive supportive measures. TEFs are associated with significant morbidity and mortality, and current therapeutic strategies remain limited. However, promising advances in endoscopic modalities and reconstructive surgery are emerging. Management necessitates a multidisciplinary, individualized approach, although standardized guidelines are currently lacking. Our case underscores the need for vigilance in patients at risk for TEF and the critical importance of early diagnosis and tailored intervention to prevent life-threatening complications.
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