ArticleSmart molecules : open access2023
Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe.
Article in Smart molecules : open access, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- An azo substituted quinoline-malononitrile enzyme-activable aggregation-induced emission nanoprobe for hypoxia imaging.Smart molecules : open access · 2025Article
- Design and computational screening of high-energy, low-sensitivity bistetrazole-based energetic molecules.RSC advances · 2025Article
- Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems.Chemical science · 2024Review
- Electron-withdrawing inductive effects enhanced strategy for protein thiol sensing and blocking agent design.Smart molecules : open access · 2024Article
- Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe.Smart molecules : open access · 2023Article
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5 authors.
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Abstract
Fluorescent probes based on rhodamine skeleton are extensively used in biological imaging. However, the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluorophores is still challenging. Herein, we propose an effective method to construct a rhodamine-based ratiometric fluorescent probe through the regulation of electron cloud density. A ratiometric fluorescent probe RDQF-RB-NTR was successfully constructed for the detection of nitroreductase (NTR). RDQF-RB-NTR exhibits good sensitivity, high selectivity, and ratiometric response to NTR. Cell imaging experiments showed that RDQF-RB-NTR can rapidly and accurately detect the fluctuation of NTR in cells and difference of NTR levels between normal cells and cancer cells. In addition, RDQF-RB-NTR was successfully applied to the imaging of NTR in liver tissue slices, and we found that the level of NTR was upregulated in liver cirrhosis.
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