Cytotoxic and Apoptotic Effects of Tin(IV) Complexes Containing a Schiff Base Derived from Cephalexin on a Breast Cancer Cell Line.

Abeer Erfan, Emad Yousif, Ahmed Alshanon, Dina S Ahmed, Benson M Kariuki, Gamal A El-Hiti

Abstract read

In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Abeer ErfanDepartment of Chemistry, College of Science, University of Baghdad, Baghdad, 64021 Iraq.

Emad YousifDepartment of Chemistry, College of Science, University of Baghdad, Baghdad, 64021 Iraq.ORCID 0000-0003-1458-4724

Ahmed AlshanonCenter of Biotechnology Research, University of Al-Nahrain, Baghdad, 64021 Iraq.

Dina S AhmedDepartment of Chemical Industries, Institute of Technology-Baghdad, Middle Technical University, Baghdad, 10074 Iraq.

Benson M KariukiSchool of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT UK.

Gamal A El-HitiDepartment of Optometry, College of Applied Medical Sciences, King Saud University, 11433 Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal complexes containing heterocycles have wide pharmaceutical and medicinal applications. The biological activities of the complexes are influenced by a range of factors, including the identity of the ligands coordinated to the tin ion and the heteroatoms contained in them. Additionally, stabilizing the bonds between the tin atom and the ligand impacts the effectiveness of organotin complexes as biologically active molecules. This study involves the synthesis of new metal complexes and their evaluation for cytotoxic and apoptotic effects against human breast cancer cells (MCF-7). The reaction of cephalexin and 4-(dimethylamino)benzaldehyde in boiling methanol gave the corresponding Schiff base in a good yield. Subsequently, the reactions of disubstituted (methyl, butyl, and phenyl) tin chlorides and the Schiff base in boiling methanol produced the corresponding organotin(IV) complexes in high yields. The effect of the synthesized organotin complexes on MCF-7 was assessed. Based on the half-maximal inhibitory concentration (IC

Indexed as

Anticancer activitiesHuman breast cancer cell lineInhibitory concentrationMTT assaySchiff baseTin(IV) complexes

Identifiers

PMID40625605

DOI10.1007/s12291-024-01207-x

PMCPMC12229414

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.