ArticleIndian journal of clinical biochemistry : IJCB2025
Assessing Colorectal Cancer Susceptibility in Kashmir, India: Insights from Xenobiotic Metabolism Gene Variants and Family Cancer History-A Comprehensive Case-Control Study.
Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Molecular insights into the anticancer properties of dieckol: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Downregulation of Hedgehog Interacting Protein (HHIP) in Gastric Cancer: Implications for Tumorigenesis.Indian journal of clinical biochemistry : IJCB · 2025Article
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Abstract
A family history of cancer(FHC) is a known risk factor for CRC with both genetic and other factors. A case-control study was conducted to assess the association between FHC and CRC risk in Kashmir, India, with a detailed analysis of epidemiological data and information on multiple gene polymorphisms. We collected detailed information on FHC and a number of socio-demographic and lifestyle factors, and also obtained blood samples for genetic analysis from 246 histopathologically confirmed CRC cases and 246 individually matched controls. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). The study participants diagnosed with colorectal cancer (CRC) exhibited a robust correlation with a positive family history of CRC. In terms of gender-based analysis, it was observed that males with CRC and a family history of CRC had an odds ratio of 16.45 (95% CI; 2.14-126.26), whereas females exhibited an odds ratio of 4.11 (95% CI; 0.84-20.03). Furthermore, individuals with affected parents showed an almost fivefold increase (OR = 4.70, 95% CI: 0.98-1.06), underscoring the substantial association. Our study unveiled significant correlations between Xenobiotic gene variants and the risk of colorectal cancer (CRC). Among individuals without a family history (FH-), those with the CYP2A6a gene variant (*1A/*6 and *6/*6 genotypes) exhibited a substantial 2.03-fold increase in CRC risk (OR = 2.03, 95% CI = 1.17-3.51,
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