ArticlePediatric discovery2023
A transcriptomic landscape analysis of human necrotizing enterocolitis: Important roles of immune infiltration.
Article in Pediatric discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.World journal of pediatric surgery · 2026Article
- Shared immune biomarkers in necrotizing enterocolitis and neonatal sepsis identified via bioinformatics and machine learning.Scientific reports · 2025Article
- Selenium deficiency is functionally linked with the molecular etiopathogenesis of necrotizing enterocolitis (NEC).Functional & integrative genomics · 2025Article
- The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis.Microorganisms · 2023Review
- A transcriptomic landscape analysis of human necrotizing enterocolitis: Important roles of immune infiltration.Pediatric discovery · 2023Article
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Authors and funding
5 authors.
Funding
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Abstract
Necrotizing enterocolitis (NEC) is one of the most common and destructive diseases in neonates and an unpredictable surgical emergency. However, the molecular pathological mechanism of NEC is still not well understood. This study was designed to provide a molecular basis for the pathogenesis of human NEC through bioinformatics analysis and immune infiltration. For RNA-Seq, DEseq2 algorithm was used to identify differentially expressed genes (DEGs) and to perform functional enrichment analysis. Immune infiltration was analyzed by CIBERSORT algorithm. A total of 34,712 genes were detected and 7463 DEGs were identified in this study. Gene Ontology analysis revealed that DEGs were mainly involved in CCR1 chemokine receptor binding, transporter activity, growth factor binding, etc. KEGG pathway analysis showed that the DEGs were significantly enriched in the toll-like receptor signaling pathway, Th17 cell differentiation, and cytokine-cytokine receptor interaction. The immune infiltration profiles varied significantly between NEC, NEC self-control, and normal intestinal tissues. Finally, the expression levels of 21 DEGs were verified by reverse transcription quantitative real-time PCR. Our findings may provide new insights into the development of NEC.
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