ArticleSmart molecules : open access2025
A β-galactosidase activated near-infrared fluorescent probe for tracking cellular senescence in vitro and in vivo.
Article in Smart molecules : open access, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- pKa engineering of a near-infrared fluorescent probe for sensitive imaging of oxidative stress in atherosclerotic plaques.Smart molecules : open access · 2026Article
- Rational design of a lipophilic β-galactosidase-responsive near-infrared probe for in vivo imaging of cellular senescence.Smart molecules : open access · 2026Article
- A Tissue-Homologous Keratin-PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment-Adaptive Repair of Chronic Diabetic Wounds.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Revisiting small-molecule fluorescent probes in food freshness detection.Smart molecules : open access · 2026Review
- A lysosome-targeted ultra-sensitive viscosity probe for monitoring viscosity alterations during chemotherapy.Smart molecules : open access · 2026Article
- A novel water-soluble near-infrared fluorescent probe for monitoring viscosity fluctuations in plants and zebrafish under abiotic stresses.Smart molecules : open access · 2026Article
- Donor Modulation of Strong Near-Infrared Lipid-Droplet Probes for in Vivo Diagnosis of Nonalcoholic Fatty Liver Disease.Chemical & biomedical imaging · 2026Article
- A Caspase-3-Activatable Near-Infrared AIEgen for Tumor Apoptosis Imaging In Vivo.Chemical & biomedical imaging · 2026Article
- Fast-Response Mitochondria-Targeted Fluorescent Probe for HChemical & biomedical imaging · 2025Article
- Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy.JACS Au · 2025Article
- A dual-enzyme activated fluorescent probe for precise identification of tumor senescence.Chemical science · 2025Article
- A β-galactosidase activated near-infrared fluorescent probe for tracking cellular senescence in vitro and in vivo.Smart molecules : open access · 2025Article
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6 authors.
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Abstract
Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause senescence in neighboring healthy cells, inducing the onset of several diseases, such as inflammation, neurological disorders, and atherosclerosis. Therefore, early detection of cellular senescence is extremely important. β-Galactosidase (β-gal), as a critical marker of cellular senescence, can be monitored to facilitate early diagnosis of aging-related diseases. Furthermore, β-gal is mainly found in lysosomes, which have a pH value of about 4.5-5.5. Here, we developed a near-infrared fluorescent probe (QMOH-Gal) for tracking cell senescence in vitro and in vivo via the detection of β-gal. In addition, the probe displayed high sensitivity and specificity for β-gal with good fluorescence signal in the acidity range. Subsequently, this QMOH-Gal probe was successfully employed to differentiate between normal cells and senescent cells by monitoring β-gal. Furthermore, the probe not only realized the monitoring of β-gal in zebrafish but also the tracking of β-gal in palbociclib-induced breast tumor senescence. Overall, the probe shows great promise as an effective tool for imaging β-gal in vivo for studying the biology of aging in organisms.
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