ArticleSmart molecules : open access2024
Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy.
Article in Smart molecules : open access, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mitochondria-Damaging Self-Reporting Probe for Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis, modification, and chlorhexidine loading of polymer modified-HM-HAP particles: In vivo antibacterial analysis and cell cytotoxicity assessment.Smart molecules : open access · 2026Article
- A synergistic strategy of AIE and electron asymmetry anchored in covalent organic frameworks for enhanced periodontitis photodynamic therapy.Materials today. Bio · 2026Article
- Artificial polysaccharide-binding protein mediates co-assembly of nanodrug and probiotics against drug-resistant infectious enteritis.Asian journal of pharmaceutical sciences · 2025Article
- Naphthalimide-Based Type-I Nano-Photosensitizers for Enhanced Antitumor Photodynamic Therapy: HAngewandte Chemie (International ed. in English) · 2025Article
- Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy.JACS Au · 2025Article
- Ring-fused chlorin-enhanced photodynamic therapy for effective cell death induction in endometrial cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- A self-reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy.Smart molecules : open access · 2024Article
- Photodynamic therapy promotes hypoxia-activated nitrogen mustard drug release.Smart molecules : open access · 2024Article
- Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy.Smart molecules : open access · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione (GSH)-activated prodrugs are promising for overcoming the limitations of conventional anti-tumor drugs. However, current GSH-responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug release rate. We herein report a series of GSH-responsive prodrugs with a "three-in-one" molecular design by integrating a fluorescence report unit, stimuli-responsive unit and chemodrug into one scaffold with tunable aromatic nucleophilic substitution (S
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