Evidence map›Paper›PMID 40625413›Full record

ArticleRSC advances2025

Effective synthesis of benzodiazepine sulfonamide-based MGAT2 inhibitors and evaluation of their antitumor activity.

Yuying Zhang, Yalei Li, Xiaoyue Liu, Yi Wang, Huachuan Zheng, Dejun Zhou

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuying ZhangThe Key Laboratory of Chinese Medicine Research, Development of HeBei province, Traditional Chinese Medicine Institute of Chengde Medical University Chengde 067000 China zhoudj20220307@163.com zhoudj202207@cdmc.edu.cn.
Yalei LiDepartment of Surgery, The Affiliated Hospital of Chengde Medical University Chengde 067000 China.
Xiaoyue LiuThe Key Laboratory of Chinese Medicine Research, Development of HeBei province, Traditional Chinese Medicine Institute of Chengde Medical University Chengde 067000 China zhoudj20220307@163.com zhoudj202207@cdmc.edu.cn.
Yi WangThe Key Laboratory of Chinese Medicine Research, Development of HeBei province, Traditional Chinese Medicine Institute of Chengde Medical University Chengde 067000 China zhoudj20220307@163.com zhoudj202207@cdmc.edu.cn.
Huachuan ZhengCancer Center, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001 China zheng_huachuan@hotmail.com.
Dejun ZhouThe Key Laboratory of Chinese Medicine Research, Development of HeBei province, Traditional Chinese Medicine Institute of Chengde Medical University Chengde 067000 China zhoudj20220307@163.com zhoudj202207@cdmc.edu.cn.ORCID https://orcid.org/0000-0001-6432-1493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study synthesized benzodiazepine sulfonamide-based MGAT2 inhibitors to combat cancer recurrence and resistance. Despite modest effects, compounds 13 and 16 showed enhanced antitumor activity. The six-step synthesis method using amino acids is industrially viable, offering a basis for future drug development.

Identifiers

PMID40625413
PMCPMC12232038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.